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Monitor Closely (1)pentobarbital will boost the amount or result of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.Contraindicated (one)pentobarbital will decrease the extent or impac